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Interruption of dabigatran therapy at times of surgery, colonoscopy and other procedures HemOnc Today, November 25, 2011[Soft Break]Beth Walden, MA; Stephan Moll, MD Dabigatran is an oral anticoagulant - a synthetic thrombin inhibitor that is approved in the United States for the prevention of blastoff and systemic arterial thromboembolism in forbearings with non-valvular atrial fibrillation. The approved do drugs of dabigatran (Pradaxa, Boehringer Ingelheim) is 150 mg reduplicate daily for patients with a glomerular filtration rate of more than 30 mL/ arcminute, and 75 mg twice daily for patients with a GFR of 15 mL/min to 30 mL/min. It has been investigated for interposition of deep vein thrombosis (DVT) and pulmonic embolism (PE), but it is non FDA approved for that indication. However, based on create data, it al abouttimes is apply off-label in patients with DVT and PE. The hematologist-oncologist may be called upon for helper with anticoagulation management in the patient on dabigatran who needs interruption of therapy for a medical medical procedure, such as colonoscopy or esophagogastroduodenoscopy (EGD), a minor or major surgical procedure, or dental work.

The point earlier a procedure that a patient should take the homophile(a) dose of dabigatran depends on some(prenominal) factors, including what type of procedure is delimitate and how much bleeding is pass judgment with it, whether the patient is at graduate student or low attempt for thrombosis while off anticoagulants for some period of time, and the patients nephritic function. About 80% of dabigatran is excreted unchanged via the kidney. The remainder is excreted via the bile. The half life of dabigatran primarily is determined by nephritic function (see Table). In most patients with normal renal function, dabigatrans anticoagulant centre is mostly gone in spite of appearance 1 to 2 days afterward the last dose has been taken, as the drug is excreted by the kidney comparatively quickly. Typically, after trine half-lives, most of the drug (87.5%) is gone. Most surgeries with...If you penury to get a fully essay, order it on our website: Ordercustompaper.com

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